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5-HTP Plus+

What is 5-HTP Plus+?

5-HT P is a building block of serotonin, the “feel good” neurotransmitter that regulates our moods, sleep cycles, and even influences our response to pain. NatureWise 5-HTP Plus+ includes vitamin B6 to aid in the conversion of 5-HTP to serotonin.  5-HTP Plus+ is included in our weight management category of products.

What is 5-HTP Plus+ used for?

For years, 5-HTP has been a popular holistic alternative to pharmaceutical antidepressants that also work on serotonin levels. In addition to supporting mood, 5-HTP has also been found to have benefit in regulating sleep and in the management of chronic pain.*

NatureWise 5-HTP Plus+ has natural mood-enhancing ingredients to promote well-being and stress reduction, and improve sleep. Early evidence suggests that supplementation with 5-HTP may promote weight loss by helping to reduce appetite and caloric intake.*


How does 5-HTP Plus+ work?

5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin is one of the principal neurotransmitters associated with happiness and anti-depression. We have included vitamin B6 in our formula to aid in the conversion of 5-HTP to serotonin in the brain.

What are the ingredients?

  • 5-HTP (5-hydroxytryptophan) (200 mg) is an amino acid derived from the seeds of the Griffonia plant.
  • Vitamin B6 (5 mg) is a water-soluble vitamin that helps to catalyze 5-HTPs conversion to serotonin.

What kind of capsules are used?

NatureWise 5-HTP Plus+ is encapsulated in vegetarian DRcaps®,  specialized delayed release capsules that will not begin to dissolve until they pass through the stomach, which may prevent or alleviate the stomach discomfort sometimes reported with larger doses of 5-HTP.*

Are there any side effects/tolerance issues with 5-HTP supplementation?

The most commonly reported side effect of 5-HTP supplementation is gastrointestinal upset. For most people, this tends to be mild and transient. To reduce potential stomach upset 5-HTP should be taken with meals and with a full glass of water.

Additionally, NatureWise 5-HTP Plus+ uses DRcaps®, which are specialized delayed release capsules. DRcaps® will not dissolve until they pass through the stomach, and may prevent or alleviate the stomach discomfort sometimes reported with larger doses of 5-HTP.*

Can I take 5-HTP Plus+ with other NatureWise weight management products?

Yes, NatureWise weight management products can be taken together.

Is 5-HTP Plus+ safe?

To date, and to the best of our knowledge, there are no published reports or studies suggesting that it is unsafe. Before taking any supplement or medication, it is always advisable to contact your healthcare provider.

Long-term use

To our knowledge, there are no published studies that investigate long-term use of 5-HTP.

Note: The duration of time for which a product is investigated does not necessarily equate with the actual duration of its safety. For example, although some of our safety data may not go beyond 6 months, 12 weeks, or even 6 weeks, it does not mean that it is unsafe to use past this time frame.This is only the information provided by published research available to date. There may be ongoing studies investigating the safety of any given product and/or ingredient that well exceed the length of the available publications.  The products that NatureWise manufactures are considered safe and backed by research.

Pregnancy and breast-feeding

Women who are pregnant or breast-feeding should avoid use, since there is insufficient reliable information in this population.

Are there any drug or food interactions reported with the ingredients in 5-HTP Plus+?

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new medication or supplement.

To date, it is generally accepted that 5-HTP should not be taken with any combination of:

●      Antidepressants, including but not limited to:

○      fluoxetine (Prozac)

○      paroxetine (Paxil)

○      sertraline (Zoloft)

○      amitriptyline (Elavil)

○      clomipramine (Anafranil)

○      imipramine (Tofranil)

○      and others

●      MAOIs (monoamine oxidase inhibitors), including but not limited to:

○      phenelzine (Nardil)

○      tranylcypromine (Parnate)

○      and others

●      Any drugs with sedative or serotonergic properties, including but not limited to:

○      carbidopa (Lodosyn)

○      dextromethorphan (Robitussin DM, and others)

○      meperidine (Demerol)

○      pentazocine (Talwin)

○      clonazepam (Klonopin)

○      lorazepam (Ativan)

○      phenobarbital (Donnatal)

○      zolpidem (Ambien)

○      tramadol (Ultram)

○      and others

●      Any herbs with sedative or serotonergic properties

○    calamus

○    California poppy

○    catnip

○    hops

○    Jamaican dogwood

○    kava

○    St. John's wort

○    skullcap

○    valerian

○    yerba mansa

○     Hawaiian baby woodrose

○    L-tryptophan

○    S-adenosylmethionine (SAMe)

○    and others

What else do I need to know about NatureWise 5-HTP Plus+?

5-HTP Plus+ is manufactured in the USA using non-GMO, vegan, and gluten-free ingredients. Each capsule contains 200 mg of 5-HTP and 5 mg of vitamin B6. Other ingredients include hypromellose and gellan gum (capsule), and organic rice bran extract. NatureWise 5-HTP Plus+ does not have yeast, wheat, gluten, dairy, corn, soy, eggs, sugar, tree nuts, peanuts, fish, shellfish, or hydrogenated oils.

Why is rice bran extract used in the formula?

At NatureWise we strive to produce the highest quality products on the market. The use of rice bran extract in our formula helps keep the highly concentrated extract from clumping together inside the capsule, reducing the “chalky” effect that you may experience with other products. Our rice bran extract is certified organic, gluten-free, has nutritious tocotrienol (a form of vitamin E), and is easy to digest.  

There is a lot of misinformation about nutritional supplements -- so much so that many manufacturers do not list all ingredients in their labeling. We’re proud of the ingredients we use, and our products are formulated to consistently deliver the highest quality, purity, and potency.

FDA Disclaimer About Health Claims

Please note that the following statement is required to accompany any health claim, such as “may promote weight loss by helping to reduce appetite and caloric intake.” It appears on all NatureWise labels and sales copy.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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